Investigator: Shoshana Greenberger, MD Phd
Institution: Sheba Medical Center (Ramat Gan, Israel)
Title of Project: Vertebrate based model for targeting overactivation of nras pathway in GLA

Investigator: Mike Dellinger, PhD
Institution: UT Southwestern Medical Center (Dallas, TX)
Title of Project: Development and characterization of an animal model of Gorham-Stout disease

Investigator: Erik Eklund, MD Phd
Institution: Lund University (Lund, Sweden)
Title of Project: Immunohistochemical features of lymphangiomatosis and Gorham’s disease

Investigator: Ionela Iacobas, MD
Institution: Baylor College of Medicine (Houston, TX)
Title of Project: Lymph-loss Markers as Predictors of Severity in Generalized Lymphatic Anomaly and Gorham-Stout Disease

Investigator: Donald McDonald, MD PhD
Institution: University of California, San Francisco (San Fransisco, CA)
Title of Project: Transgenic mouse model to determine the mechanism and treatment of congenital pulmonary lymphangiectasia and lymphangiomatosis

Investigator: Ramani Ramchandran, PhD
Institution: Medical College of Wisconsin (Milwaukee, WI)
Title of Project: Molecular crosstalk and matrix metalloproteinases in generalized lymphatic anomaly (GLA) and gorham-stout syndrome (GSS) patients

Investigator: Eva Sevick, Phd
Institution: UT Health Science Center at Houston (Houston, TX)
Title of Project: Imaging lymphatic function in normal subjects and persons with lymphatic disorders

Investigator: Cameron Trenor, MD
Institution: Boston Children’s Hospital (Boston, MA)
Title of Project: Lymphatic anomalies database

Investigator: Lianping Xing, B.Med., PhD
Institution: University of Rochester (Rochester, NY)
Title of Project: Bone cells and lymphatic endothelium interface

Investigator: Miikka Vikkula, MD PhD
Institution: Universite Catholique de Louvain (Brussels, Belgium)
Title of Project:Molecular Pathogenesis of Lymphatic Anomalies

Investigator: Denise Adams, MD
Institution: Boston Children’s Hospital (Boston, MA)
Title of Project: The Lymphatic Registry






Investigators: Maxim Itkin, MD and Yaov Dori, MD

Institution: University of Pennsylvania (Philadelphia, PA)

Award: $101,000

Title of Project: Dynamic Contrast Enhanced MR Lymphangiogram Imaging of Lymphatic Anomalies

Investigator: David Cormode, PhD

Institution: University of Pennsylvania (Philadelphia, PA)

Award: $51,000

Title of Project: Nano-magnetic Oils for the Study of Intestinal Lymphatics in Lymphangiomatosis

Investigator: Joseph Rutkowski, PhD

Institution: Texas A&M Health Science Center School of Medicine (College Station, TX)

Award: $51,000

Title of Project: Inducible Lymphatic Hyperplasia to Drive Chylous Accumulation Mimicking Lymphangiomatosis




Investigator: Andrea Del Fattore, PhD and Andrea Bartuli, MD

Institution: Bambino Gesù Children’s Hospital (Rome, Italy)

Award: $59,00

Title of Project: Understanding the molecular and cellular defects of bone remodeling in patients affected by Gorham-Stout disease (GSD)

Investigator: Carrie Shawber, PhD

Institution: Columbia University Medical Center (New York, New York)

Award: $101,000

Title of Project: Identification of the Genetic Causes of Generalized Lymphatic Anomalies




Investigator: J. Brandon Dixon, PhD

Institution: Georgia Tech (Atlanta, GA)

Award: $80,000

Title of Project: Tissue Engineered Lymphatic Malformation on a Chip for Screening Therapeutics

Investigator: Denise Adams, MD

Institution: Boston Children’s Hospital (Boston, MA)

Award: $50,000

Title of Project: Retrospective analysis of the safety and efficacy of lymphatic anomalies of the bone (Generalized Lymphatic anomaly (GLA), Gorham Stout Disease (GSD), Channel type Lymphatic Malformation (CTLM)) treated with mTOR inhibition and bisphosphonates




Investigator: Shoshana Greenberger, MD PhD

Institution: Sheba Medical and Tel-Aviv University, Israel (Ramat Gan, Israel)

Award: $50,000

Title of Project: Role of NRAS mutations in the pathology of generalized lymphatic anomaly

Investigator: Andrew Del Fattore, PhD

Institution: Bambino Gesù Children’s Hospital, IRCCS (Rome, Italy)

Award: $50,000

Title of Project: Analysis of crosstalk between regulatory T and bone cells in Gorham-Stout



Investigator: Julie Blatt, MD

Institution: University of North Carolina, Chapel Hill (Chapel Hill, North Carolina)

Award: $63,000

Title of Project: Pilot study

Through this pilot study, Dr. Blatt and her team seek to develop a model with which to test the repurposing of antiangiogenic drugs in treating lymphatic malformations.