The MDBR award is funded by LGDA, LGD Alliance Europe, and LMI
Year: 2024
Investigator: Shoshana Greenberger, MD, PhD
Institution: Sheba Medical Center and Tel Aviv University (Tel Aviv, Israel)
Award: $62,398
Title of Project: Deciphering the Role of Ephrin B2 Mutation in the Pathogenesis of Central Conducting Lymphatic Anomaly
Year: 2023
Investigator: Brian Sisk, MD
Institution: Washington University (St. Louis, MO)
Award: $60,679
Title of Project: CLA Chatbot: Developing a Scalable Artificial Intelligence-Powered Communication Tool for Families Affected by Complex Lymphatic Anomalies
Year: 2022
Investigator: Karina Yaniv
Institution: Sheba Medical Center (Tel Aviv, Israel)
Award: $68,650
Title of Project: A novel Zebrafish model of Kaposiform Lymphangiomatosis: A tool for drug discovery
Year: 2022
Investigator: Michela Rossi, PhD
Institution: Bone Physiopathology Research Unite, Bambino Gesu Children’s Hospital (Rome, Italy)
Mentor: Andre Del Fattore
Young Investigator Award: $25,000
Title of Project: Analysis of a new therapeutic approach to inhibit osteolysis in Gorham-Stout Disease
Year: 2022
Investigator: Silvia Martin Almedina, Senior Postdoctoral Fellow
Institution: St. George’s University of London (London, England)
Mentor: Pia Ostergaard
Young Investigator Award: $25,000
Title of Project: Molecular mechanisms of EPHB4 pathogenesis – towards new treatment development for lymphatic anomalies
Year: 2021
Investigator: Brian Sisk, MD
Institution: Washington University School of Medicine (Saint Louis, MO)
Award: $53,460
Title of Project: Identifying Unmet Care and Communication Needs of Families Affected by Complex Lymphatic Anomalies
Year: 2020
Investigator: Andrea Del Fattore, PhD
Institution: Bambino Gesù Children’s Hospital, IRCCS (Rome, Italy)
Award: $81,965
Title of Project: Understanding the effects of Sirolimus/Zolendronic acid treatment bone remodeling activity in patients with Gorham-Stout disease
Year: 2019
Investigator: Julie Blatt, MD
Institution: University of North Carolina, Chapel Hill (Chapel Hill, North Carolina)
Award: $62,861
Title of Project: Engineered microvessels derived from lymphatic endothelium as an in vitro model for drug repurposing for lymphatic malformations
Year: 2018
Investigator: Shoshana Greenberger, MD PhD
Institution: Sheba Medical and Tel-Aviv University, Israel (Ramat Gan, Israel)
Award: $50,535
Title of Project: Role of NRAS mutations in the pathology of generalized lymphatic anomaly
Year: 2018
Investigator: Andrea Del Fattore, PhD
Institution: Bambino Gesù Children’s Hospital, IRCCS (Rome, Italy)
Award: $50,535
Title of Project: Analysis of crosstalk between regulatory T and bone cells in Gorham-Stout
Year: 2017
Investigator: J. Brandon Dixon, PhD
Institution: Georgia Tech (Atlanta, GA)
Award: $80,000
Title of Project: Tissue Engineered Lymphatic Malformation on a Chip for Screening Therapeutics
Year: 2017
Investigator: Denise Adams, MD
Institution: Boston Children’s Hospital (Boston, MA)
Award: $52,109
Title of Project: Retrospective analysis of the safety and efficacy of lymphatic anomalies of the bone (Generalized Lymphatic anomaly (GLA), Gorham Stout Disease (GSD), Channel type Lymphatic Malformation (CTLM)) treated with mTOR inhibition and bisphosphonates
Year: 2016
Investigator: Andrea Del Fattore, PhD and Andrea Bartuli, MD
Institution: Bambino Gesù Children’s Hospital (Rome, Italy)
Award: $59,000
Title of Project: Understanding the molecular and cellular defects of bone remodeling in patients affected by Gorham-Stout disease (GSD)
Year: 2016
Investigator: Carrie Shawber, PhD
Institution: Columbia University Medical Center (New York, New York)
Award: $101,000
Title of Project: Identification of the Genetic Causes of Generalized Lymphatic Anomalies
Year: 2015
Investigators: Maxim Itkin, MD and Yaov Dori, MD
Institution: University of Pennsylvania (Philadelphia, PA)
Award: $101,000
Title of Project: Dynamic Contrast Enhanced MR Lymphangiogram Imaging of Lymphatic Anomalies
Year: 2015
Investigator: David Cormode, PhD
Institution: University of Pennsylvania (Philadelphia, PA)
Award: $51,000
Title of Project: Nano-magnetic Oils for the Study of Intestinal Lymphatics in Lymphangiomatosis
Year: 2015
Investigator: Joseph Rutkowski, PhD
Institution: Texas A&M Health Science Center School of Medicine (College Station, TX)
Award: $51,000
Title of Project: Inducible Lymphatic Hyperplasia to Drive Chylous Accumulation Mimicking Lymphangiomatosis